Download this image now with a free trial. The OSE-CIC model can account for several important features of ovarian tumorigenesis, including (1) acquisition of Müllerian characteristics by OSE-derived tumors, (2) the cystic nature of benign ovarian tumors and the retention of cystic features by their malignant counterparts, and (3) the presence of low-grade and borderline tumors within the cortical stroma of the ovary. Describe the ovarian stroma in detail along with a diagram. © Copyright PathologyOutlines.com, Inc. Click, Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2015;37:309, Int J Gynecol Pathol 2018 Aug 21 [Epub ahead of print], Crum: Gynecologic and Obstetric Pathology, 3rd Edition, 2017, Metastatic thyroid carcinoma to the ovary, Appl Immunohistochem Mol Morphol 2011;19:293, Monodermal ovarian teratoma primarily (> 50%) or exclusively composed of benign thyroid tissue, Ovarian teratoma either composed predominantly or exclusively of benign thyroid tissue or with any amount of malignant thyroid tissue, Most common thyroid malignancy to occur in struma ovarii is, Most often an incidental and asymptomatic finding but may present as a pelvic mass with abdominal pain (, Diagnosis is made by microscopic examination of resected tissue, Mildly increased CA125 levels in up to 30% of cases (, Typically a lobulated and multiloculated solid cystic lesion on imaging (, MRI is more specific, showing high and low signal intensity on T1 and T2 weighted images from the colloid (, Most cases have a good prognosis, even when malignancy is present, 10 year old girl with tachycardia, normal thyroid and thyrotoxicosis with papillary thyroid carcinoma arising from a struma ovarii (, 48 year old woman with malignant struma ovarii presenting 14 years after oophorectomy and chemotherapy (, 52 year old woman with clinical features of advanced ovarian carcinoma found to have a struma ovarii (, 61 year old woman with insular carcinoma (90%) and adjacent papillary thyroid carcinoma arising in a struma ovarii (, 62 year old woman with 2 different types of, 74 year old woman with a mixed ovarian tumor composed of elements of Brenner tumor, mucinous cystadenoma and struma ovarii (, Surgery for malignant struma ovarii may include total abdominal hysterectomy and bilateral salpingo-oophorectomy with complete staging (, Typically unilateral and solid with a gelatinous, red-brown to green cut surface; may show goiter-like multinodular or cystic change (, Variably sized macro and microfollicles often containing colloid, Other architectural patterns include solid areas composed of cells with clear to oxyphilic cytoplasm, trabeculae, cords and pseudotubular structures, Rarely, stroma in between follicles may be fibrotic or edematous; peripheral stromal leutinization may also be seen, Adenomatous hyperplasia or proliferative changes may be seen, such as areas of densely packed follicles or papillary formations lacking nuclear features of, Uncommonly associated with the more recently described highly differentiated follicular carcinoma of ovarian origin, characterized by extraovarian spread of thyroid elements histologically resembling nonneoplastic thyroid tissue (, Flattened to cuboidal / columnar cells with small round to oval nuclei, even chromatin and pale to eosinophilic cytoplasm (, Clear cell change may occasionally be seen. Bundles of smooth muscle cells are scattered throughout the stroma. The lower pole is directed towards the wall of the uterus, and is attached to the uterine wall by the ovarian ligament. 30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA). Cells from nearby intraabdominal locations can attach to the ovary, causing the ovarian stroma and other ovarian tissues to interact with these new cells causing cellular growth and metastasis (Danhausen et al., 2019). The cortex is composed of a tissue framework called the ovarian stroma that forms the bulk of the adult ovary. Tweet. Scale to any size without loss of resolution. Symptoms become more noticeable as the cancer progresses. Under normal circumstances, the ovarian stroma provides a structural framework undergoing dynamic changes to support follicular growth. The growth and development of ovarian follicles will be described shortly. This group of tumors accounts for 90% to 95% of all cases of ovarian cancer. Oocytes develop within the outer layer of this stroma, each surrounded by supporting cells. Central diagram of a human ovary (adapted from Gray 1918) surrounded by boxes highlighting different ovarian stromal components including (clockwise from top center): immune cells including macrophages, dendritic cells, neutrophils, eosinophils, mast cells, B & T cells, and Natural Killer (NK) cells; incompletely characterized stromal cells (including fibroblast-like, … Metastatic ovarian carcinomas, especially Krukenberg tumors, may have a predominantly solid appearance (, 44,, 45). It can be increased in up to 30% of struma ovarii. It is wrapped by a layer of cuboidal cells, the germinal epithelium, followed by a flattened cell layer known as visceral peritonium. The stroma of the ovary is a unique type of connective tissue abundantly supplied with blood vessels, consisting for the most part of spindle-shaped stroma cells. This grouping of an oocyte and its supporting cells is called a follicle. We welcome suggestions or questions about using the website. Diagramatic Representation Normal Human Ovary Labeled Stock Vector (Royalty Free) 47963926. Ovarian cancer is a cancer that forms in or on an ovary. When this process begins, there may be no or only vague symptoms. Depending on the histologic features, struma ovarii can be classified as benign or malignant . Ovarian Stroma- Ovarian stroma is the soft connective tissue with a huge supply of blood. This peritoneal extension is called the mesovarium. Polycystic ovaries (PCO) or polycystic ovarian morphology is an imaging descriptor of a particular type of change in ovarian morphology.A proportion of women with polycystic ovaries will have the polycystic ovarian syndrome (PCOS), which in turn requires additional clinical, as well as biochemical, criteria; otherwise polycystic ovaries can be considered a normal variant. These symptoms may include bloating, pelvic pain, abdominal swelling, and loss of appetite, among others. This article have been viewed 23688 times. Figure 1 . Follicles containing oocytes in various stages of development. A single, dominant follicle develops. Oocytes develop within the outer layer of this stroma, each surrounded by supporting cells. 17-OH-progesterone = 17-hydroxyprogesterone. Ovary in zoology female reproductive organ in which sex cells eggs or ova are produced. Vector. The lateral surface of the ovary is … Which laboratory marker may be elevated with struma ovarii? The entire ovarian stroma is highly vascular.[1]. Stromal cells associated with maturing follicles may acquire endocrine function and secrete estrogens. Ovarian tumors can arise from the migration of cells from mesoderm originating tissues to the surface of the ovary (Danhausen et al., 2019). The developing oocyte and its surrounding scaffolding rely on endocrine, paracrine, and autocrine signaling mechanisms to maintain cell-to-cell communication and assure synchronized … The stroma also contains ordinary connective tissue such as reticular fibers and collagen. Your rating: none, Average: 4.3 (7 votes) Rate it. This type of cancer is more prevalent in women over the age of 50, but roughly 5% of ovarian stromal tumors … Filed under Surgery. And now everything in detail! The outer layer is the ovarian cortex, consisting of ovarian follicles and stroma in between them. Components of the ovarian stroma. It results in abnormal cells that have the ability to invade or spread to other parts of the body. Last modified 11/04/2015. B. CA125 is a widely accepted biomarker for ovarian cancers that can also be elevated in many other conditions, such as menstruation, endometriosis, pregnancy, pelvic inflammatory disease, fibroids, liver disease and tumors of the endometrium, breasts and lungs. This article incorporates text in the public domain from page 1256 of the 20th edition of Gray's Anatomy (1918), "Southern Illinois University School of Medicine", https://en.wikipedia.org/w/index.php?title=Stroma_of_ovary&oldid=963999021, Wikipedia articles incorporating text from the 20th edition of Gray's Anatomy (1918), Creative Commons Attribution-ShareAlike License, This page was last edited on 23 June 2020, at 00:46. The mean echogenicity was defined as the sum of the product of each intensity level (varying from 0–63) and the number of pixels for that intensity concentration divided by the total number of pixels in the measured area, as follows: Neoplasms in this group are thought to be derived from the ovarian surface epithelium or from ectopic endometrial or Fallopian tube tissue. This website is intended for pathologists and laboratory personnel but not for patients. Common areas to which the cancer may spread include the lining of the abdomen, lymph nodes, lungs, and liver. Stroma of ovary, which includes the sex cords, forerunners of endocrine apparatus . Ovarian Hormones: Structure, Biosynthesis, Function, Mechanism of Action, and Laboratory Diagnosis. The growth and development of ovarian follicles will be described shortly. Published on 11/04/2015 by admin. 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ovarian stroma diagram

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